The Power of Caloric Intake: Enhancing Muscle Health and Longevity
Caloric restriction (CR) is a dietary approach where calorie intake is reduced without malnutrition. In rodents, a 40% reduction in calorie intake has been shown to extend lifespan, delay disease onset, and improve the body's ability to handle stress. The CALERIE study delved into the effects of a 12% CR over two years in healthy humans. The results? Minor muscle mass loss without any decline in muscle strength. But how does this work? Deep dives into the muscle tissues of participants revealed changes in the expression of genes linked to various processes like DNA repair, mitochondrial creation, and inflammation. These changes hint at the preservation of muscle quality and suggest that even moderate CR can have profound benefits on muscle health and overall longevity in humans.